Ascentage Pharma today announced that results from four clinical studies of the company’s key assets, including the first China-approved third-generation BCR-ABL tyrosine kinase inhibitor (TKI) olverembatinib (HQP1351), Bcl-2 selective inhibitor lisaftoclax (APG-2575), MDM2-p53 inhibitor alrizomadlin (APG-115), and FAK/ALK/ROS1 inhibitor (APG-2449), have been selected for presentations at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting.
The ASCO Annual Meeting showcases the most cutting-edge research in clinical oncology and state-of-the-art advanced cancer therapies and is the world’s most influential and prominent scientific gathering of the clinical oncology community. This year’s ASCO Annual Meeting will take place both online and in-person at the McCormick Place, Chicago, IL, United States of America, on June 2–6, 2023.
“We are pleased to have the opportunity to present our clinical results at the ASCO Annual Meeting for the sixth consecutive year and witness the strong recognition of our global innovation and clinical development capabilities,” said Dr. Yifan Zhai, Chief Medical Officer of Ascentage Pharma. “This year, we will present the first dataset of lisaftoclax for the treatment of Waldenström macroglobulinemia (WM). In addition, we will share updated results of alrizomadlin plus pembrolizumab in patients with cutaneous melanoma, olverembatinib in patients with gastrointestinal stromal tumor (GIST), as well as APG-2449 in patients with non-small-cell lung cancer (NSCLC). Moving ahead, we will continue accelerating our global clinical development programs in efforts to bring more treatment options to patients in need.”
These four clinical studies to be presented at this year’s ASCO Annual Meeting are as follows:
Poster Discussion
APG-2449
FAK inhibition with novel FAK/ALK inhibitor APG-2449 could overcome resistance in NSCLC patients who are resistant to second-generation ALK inhibitors.
Poster Presentation
Olverembatinib (HQP1351)
Antitumor activity of olverembatinib (HQP1351) in patients (pts) with tyrosine kinase inhibitor (TKI-)- resistant succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST).
APG-2575
Preliminary data of a phase 1b/2 study of BCL-2 inhibitor lisaftoclax (APG-2575) alone or combined with ibrutinib or rituximab in patients (pts) with Waldenström macroglobulinemia (WM).
APG-115
A phase 2 study of alrizomadlin (APG-115) in combination with pembrolizumab in patients with unresectable or metastatic cutaneous melanoma that has failed immuno-oncologic (IO) drugs.